Advancing the molecular mechanisms of neurosurgical pathologies — from cerebrovascular disease to trigeminal neuralgia — through translational research at Johns Hopkins Medicine
Our laboratory investigates how mast cells drive neuroinflammation after stroke, subarachnoid hemorrhage and intracerebral hemorrhage. Using molecular and cellular techniques including Western blotting, flow cytometry, immunohistochemistry and in vitro assays together with traditional and conditional knockout models, we investigate the mechanistic pathways underlying cerebrovascular disorders.
We discovered that reactive oxygen species (ROS) drive trigeminal neuralgia pain and are developing improved translational animal models of trigeminal neuralgia to test novel therapeutics. Using artificial intelligence, computational imaging and resting-state fMRI, our work improves diagnosis, predicts surgical outcomes after microvascular decompression and maps functional brain networks.
Through comprehensive clinical outcomes research, we track, analyze, and refine neurosurgical procedures to maximize patients’ function, minimize risks and ultimately improve the quality of life.
Johns Hopkins Department of Neurosurgery
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The Johns Hopkins Hospital
1800 Orleans St, Baltimore, MD 21287
