Mrgprb2 is a receptor that is specifically expressed in mast cells. Our laboratory is working to uncover how Mrgprb2 activates mast cells in stroke, leading to downstream neuroinflammation.

Our laboratory has discovered that oxidative stress and reactive oxygen species play a critical role in pain transmission in trigeminal neuralgia.

Paper: Identification of the NRF2 transcriptional network as a therapeutic target for trigeminal neuropathic pain.